| abstract |
Compositions are provided for reducing dependence on addiction substances and addiction. Changed GABA A receptor electrophysiological properties of containing neurons, thereby providing a pathophysiological state, dependence and withdrawal symptoms, while under example as occurs anxiety dependence and withdrawal, GABA A Chlorine ion channels such as receptors are altered. Specifically, under withdrawal conditions, the relative ratio of a1 receptor subunits is reduced compared to a4 receptor subunits. Endogenous neurosteroid production is also associated with molecular changes that underlie the alteration of GABA-dependent chloride channels. Compositions of at least two compounds comprising at least one neurosteroid production inhibitor are useful for treating the pathophysiology of addiction, dependence and substance abuse withdrawal. |