http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008538549-A
Outgoing Links
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|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2006-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008538549-A |
| titleOfInvention | Biomarkers on the effectiveness of aliskiren as a hypertensive agent |
| abstract | A retrospective pharmacogenetic analysis was performed in an attempt to evaluate the possible relationship between genetic variation and clinical trial results of the effects of aliskiren as an antihypertensive agent. Forty-eight gene polymorphisms were tested in the renin-angiotensin-aldosterone system (RAS) or 12 genes already implicated in blood pressure control. 1 gene polymorphism in the angiotensin converting enzyme (ACE) gene, 2 gene polymorphisms in the angiotensin II type 2 receptor (AGTR2) gene, and a significant relationship between the mean loci and systolic blood pressure reduction clinical parameters A relationship was seen. These effects were not seen with irbesartan and placebo treatment, but instead were specific to aliskiren treatment. |
| priorityDate | 2005-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 156.