| abstract |
The present invention relates to synthetic cytoskeletal active compounds related to natural latrunculin A or latrunculin B. The invention also relates to a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier. Furthermore, the present invention relates to a method for preventing or treating a disease or condition associated with actin polymerization. In one aspect of the invention, the method treats elevated intraocular pressure, such as primary open angle glaucoma. The method comprises administering to the patient a therapeutically effective amount of a cytoskeletal active compound of formula I or II, said amount being effective to affect the cytoskeleton, eg, by inhibiting actin polymerization. Is. |