| abstract |
The present invention provides infectious self-propagating recombinant paramyxoviruses. The recombinant paramyxovirus preferably has one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus comprises a variant polynucleotide encoding a distinct P protein and a monocistronic polynucleotide encoding a distinct V protein. In some embodiments, the recombinant paramyxovirus has at least one temperature sensitive mutation and one non-temperature sensitive mutation. In addition, compositions and methods for using recombinant paramyxoviruses are also provided, as described herein. |