abstract |
Gliazine is identified as a physiological receptor for CXCR3. Assays for determining modulators of CXCR3 signaling are provided. Fragments of gliadin that function as inhibitors of CXCR3 signaling can be determined. Targeting CXCR3 provides a method for treating diseases related to gluten and / or diseases related to autoimmunity. Such diseases include celiac disease, gluten sensitivity, gluten allergy, rheumatoid arthritis, multiple sclerosis, immune-mediated diabetes or type 1 diabetes, inflammatory bowel disease, systemic lupus erythematosus, psoriasis, scleroderma, and Autoimmune thyroid disease. |