| abstract |
The present invention relates to a novel class of benzothiophenamide derivatives. Hydroxamic acid compounds can be used to treat cancer. The benzothiophenamide compound can also inhibit histone deacetylase and can be used to suppress the proliferation of the cells by selectively inducing terminal differentiation of new cells and cell growth arrest and / or apoptosis. Suitable for Thus, the compounds of the present invention are useful for treating patients with tumors characterized by neoplastic cell proliferation. The compounds of the present invention are also useful for the prevention and treatment of TRX diseases such as autoimmune diseases, allergic diseases and inflammatory diseases, and for the prevention and / or treatment of central nervous system (CNS) diseases such as neurodegenerative diseases. I think that the. The present invention further provides a pharmaceutical composition containing a hydroxamic acid derivative and a safe dosing regimen of said pharmaceutical composition that is easy to comply with and provides a therapeutically effective amount of the hydroxamic acid derivative in vivo. |