| abstract |
The present invention relates to a novel class of hydroxamic acid derivatives. This hydroxamic acid compound can be used to treat cancer. This hydroxamic acid compound can also inhibit histone deacetylase, for selective induction of tumor cell terminal differentiation, cell growth arrest and / or apoptosis, thereby inhibiting the growth of such cells. Is suitable. Accordingly, the compounds of the present invention are useful for the treatment of patients with tumors characterized by tumor cell growth. The compounds of the invention may also prevent and / or treat TRX-mediated diseases such as autoimmune diseases, allergic diseases and inflammatory diseases, and central nervous system (CNS) diseases such as neurodegenerative diseases. Useful for treatment. The present invention further provides pharmaceutical compositions comprising hydroxamic acid derivatives, and safe dosing regimens for these pharmaceutical compositions that are easy to perform and yield a therapeutically effective amount of the hydroxamic acid derivative in vivo. |