| abstract |
The present invention is Na + -K + -2Cl - reducing the effective amount of (NKCC) symporter, inactivating, and / or by administering the agent that is effective in inhibiting the activity , Methods and compositions for treating neuropathic pain and neuropsychiatric disorders. In certain embodiments, Na + -K + -2Cl - cotransporter is NKCC1. The compositions and methods of the present invention do not suppress neuronal excitability, thus avoiding the undesirable side effects often associated with drugs currently used for the treatment of neuropathic pain and neuropsychiatric disorders. It can be used to reduce neuronal hypersynchronization and / or neuropsychiatric disorders associated with disabling pain. |