| abstract |
Novel 5-substituted 7-amino [1,3] of formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification Disclosed are thiazolo [4,5-d] pyrimidine derivatives and pharmaceutically acceptable salts thereof, methods for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX 3 CR1 receptor antagonists, so that they are neurodegenerative disorders, demyelinating diseases, cardiovascular- and cerebrovascular atherosclerosis, peripheral arterial diseases, rheumatoid arthritis, lung diseases such as COPD, asthma Or, it is useful for treating or preventing pain. |