| abstract |
The present invention provides methods, compositions, formulations and kits related to acadesine or its prodrugs, analogs or salts and / or blood coagulation inhibitors for preventing or reducing side effects in patients. Beneficial patient types include patients with reduced left ventricular function, patients with a history of myocardial infarction, patients undergoing nonvascular surgery, or fetuses in labor and delivery. In one aspect, the present invention prevents or reduces side effects in patients with reduced left ventricular function with ejection fraction less than 30% by administering to the patient an effective amount of acadesine or a prodrug, analog or salt thereof. Provide a way to do it. Provides a method wherein the patient is female and / or the age is between 65 and 95 years. |