| abstract |
The present invention relates to general formula I (wherein X represents CH 2 , C═O, C═S or CHOH, X represents CH 2 , C═O, C═S or CHOH, R 1 represents 1 Represents an amino acid optionally substituted by the above halogen atoms, preferably fluorine or by one or more CF 3 groups, and n = 0, 1 or 2, or X is CH 2 , C = O, C═S or CHOH, R 1 represents a peptide containing two amino acids, each amino acid may be substituted by one or more halogen atoms, preferably fluorine, or one or more CF 3 groups Well and n = 0 or 1 or XR 1 represents PO 3 H or SO 3 H and n = 0, 1 or 2; R 2 is H, XR 1 , C 1 -C 6 alkyl group, an aralkyl group of C 1 -C 6 Or an aryl group (wherein the alkyl group, an aralkyl group and the aryl group, amine NH 2, a carboxylic acid group COOH, 1 or more halogen atoms, be advantageously substituted fluorine or by one or more CF 3 groups, Or a pharmaceutically acceptable addition salt, isomer, enantiomer and diastereoisomer of the compound, and mixtures thereof, and pharmaceutical or cosmetic compositions containing them As well as their use as AGE inhibitors to capture reactive carbonyl compounds. |