| abstract |
A first base selected from the group consisting of solid ibuprofen and sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium glycinate, potassium glycinate, tribasic sodium phosphate and potassium, and mixtures thereof A process for producing solubilized ibuprofen, preferably in the form of granules, comprising providing a mixture comprising: and reacting the ibuprofen and the first base in an essentially dry state. The granules that can be obtained, and the pharmaceutical compositions and dosage forms that can be produced therefrom, have high solubility in aqueous media and rapid disintegration and dissolution, good fluidity and compressibility, rapid analgesic effect Characterized by opening. |