| abstract |
The present invention relates to a novel potassium channel modulator of formula I having the definitions of R1-R4, X, Y and n as defined in claim 1 and its use in the preparation of pharmaceutical compositions. The invention further relates to diseases or disorders associated with the activity of potassium channels, in particular respiratory diseases, epilepsy, convulsions, vasospasm, coronary spasm, renal dysfunction, polycystic kidneys, bladder spasms, urinary incontinence, bladder outflow disorders Irritable bowel syndrome, gastrointestinal disorders, secretory diarrhea, ischemia, cerebral ischemia, ischemic heart disease, angina, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, Depression, dementia, memory impairment and attention deficit, Alzheimer's disease, dysmenorrhea, narcolepsy, Raynaud's disease, intermittent claudication, Sjogren's syndrome, migraine, arrhythmia, hypertension, absence seizure, myotonic muscle dystrophy, It is aimed at a pharmaceutical composition useful for treating or alleviating xerostomia, type II diabetes, hyperinsulinemia, premature labor, baldness, cancer, immunosuppression or pain. |