| abstract |
In this specification, a new defective Sind made from wild-type Ar-339 Sindbis virus, which differs in replicase and envelope protein between JT vector and Sindbis virus consensus sequence, and also between JT vector and Ar-339 vector. A bisvirus vector is disclosed. Also disclosed are plasmids used to make the vectors, methods for generating the vectors, methods for treating mammals suffering from tumors, and formulations for use in the methods of treatment. |