abstract |
The present invention relates to formula (X) [Chemical 1] Aryl and heteroaryl compounds of the invention are provided. The compounds of the present invention are useful as antagonists or factor IX and / or partial antagonists of factor XI and can be used to inhibit the intrinsic pathway of blood clotting. In the formula (X), R 102 represents —C (O) OH, —C (O) OCH 3 , —C (O) Ot-butyl, —C (O) NH—OCH 2 -phenyl, C ( R 101 , R 103 , R 104 and Y are defined herein, selected from the group consisting of O) NHOH and —C (O) NHSO 2 CH 3 . |