| abstract |
The present invention relates to novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or a pharmaceutically acceptable salt thereof, and optionally at least one nitric oxide enhancing compound and / or at least one therapeutic agent. Is described. The present invention also treats (a) conditions resulting from overhydration and / or electrolyte retention; (b) treats cardiovascular disease; (c) treats renovascular disease; (d) treats diabetes (E) treat diseases resulting from oxidative stress; (f) treat endothelial dysfunction; (g) treat diseases caused by endothelial dysfunction; (h) treat cirrhosis; (j) eclampsia (K) treat osteoporosis; (l) treat nephropathy; (m) treat peripheral vascular disease; (n) treat portal hypertension; (o) central nervous system Treating a systemic disorder; (p) treating a metabolic syndrome; (q) treating a sexual dysfunction; and (r) providing a method of treating hyperlipidemia. The nitric oxide enhancing diuretic compound comprises at least one nitric oxide enhancing group attached to the diuretic compound by one or more sites such as carbon, oxygen and / or nitrogen via a non-hydrolyzable bond or moiety. |