| abstract |
The invention includes numerous inflammatory conditions, migraine, rheumatoid arthritis, asthma, inflammatory bowel disease, mediation of the vomiting reflex, Parkinson's disease, anxiety, depression, psychosis, motion sickness, induced vomiting, pain, headache, migraine, Other respiratory diseases including Alzheimer's disease, multiple sclerosis, attenuated morphine withdrawal, cardiovascular changes, edema such as burned edema, chronic inflammatory diseases such as rheumatoid arthritis, asthma / bronchial hypersensitivity and allergic rhinitis For the treatment of diseases, intestinal inflammatory diseases including ulcerative colitis and Crohn's disease, eye trauma and other eye inflammatory diseases, traumatic brain injury, motion sickness, vomiting, and psychoimmune disorders or psychosomatic disorders Formula (I) wherein R 1 / R 1 ′ is hydrogen or methyl; X is —C (O) N (CH 3 ) — or —N (CH 3 ) C (O) —. And a compound represented by Histological to about acceptable acid addition salts. |