| abstract |
The present invention relates to anti-CD30 antibodies lacking fucosyl residues. The antibodies of the present invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse D30 expressing cell lines that are not lysed by fucosylated forms of the antibody. The invention also provides host cells that express anti-CD30 antibodies lacking fucosyl residues. The host cell is deficient in fucosyltransferase. Also provided are methods of using the antibody to inhibit the growth of CD30 + cells, eg, tumor cells. |