| abstract |
Demonstrates activity useful in lowering plasma glucose, cholesterol and / or triglycerides and useful in the treatment of obesity, inflammation, immune disorders, autoimmune diseases, diabetes and diseases related to insulin resistance A diphenyl ether compound of formula (I) is provided. [Chemical 1] (Wherein ---- may represent a bond; W represents O or S; Z represents CR 10 , O or S; G represents O or S or together with R 10) Forming a 5- or 6-membered aromatic or aromatic heterocyclic system containing one or two heteroatoms selected from the group consisting of O, S and N; R 8 is OR 13 or NR 14 Represents R 15 , wherein R 13 is hydrogen, substituted and unsubstituted (C 1 -C 20 ) alkyl, substituted and unsubstituted (C 2 -C 20 ) alkenyl, substituted And unsubstituted (C 5 -C 14 ) aryl, substituted and unsubstituted (C 6 -C 34 ) aralkyl, substituted and unsubstituted (C 1 -C 13 ) heteroaryl and is selected from the group consisting of counter ions, further R 14 and R 15, H, substituted and non-substituted of (C 1 -C 20) alkyl, substituted and unsubstituted forms of ( 2 -C 20) is selected alkenyl and substituted and non-substituted type (C 5 -C 14) independently from the group consisting of aryl);. Other substituents are defined in the appended claims .) |