| abstract |
The present invention comprises an organic nitric oxide donor salt of a novel antimicrobial compound, and an organic nitric oxide donor salt of at least one antimicrobial compound, and optionally at least one nitric oxide enhancing compound and / or at least one Novel compositions and kits containing therapeutic agents are described. The invention also provides a method for (a) treating a bacterial infection; (b) treating a viral infection; (c) treating a fungal infection; and (d) treating an injury. In one embodiment, the antimicrobial compounds of the invention are aztreonam, ciprofloxacin, doripenem, duramycin, and tobramycin. Organic nitric oxide donors that form salts are preferably organic nitrates, organic nitrites, nitrosothiols, thionitrites, and heterocyclic nitric oxide donors. The heterocyclic nitric oxide donor is preferably furoxan, sydnonimine, oxatriazol-5-one, and / or oxatriazole-5-imine. The method of the invention is preferably for the treatment of bacterial infections associated with pulmonary diseases such as cystic fibrosis and the treatment of Bacillus anthracis infections. |