| abstract |
Pharmaceutical compositions useful for the treatment of immune disorders are provided. The composition comprises a pharmaceutically acceptable carrier and an effective amount of a nitroxide antioxidant for treatment or prevention that alters the expression of genes associated with immune diseases. Also provided are methods of using the present pharmaceutical compositions in the treatment or prevention of immune disorders. In a preferred embodiment, the nitroxide antioxidant is Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl). The gene is one of glucocorticoid-inducible leucine zipper, collagen type Iα1, and complement component 6. The immune diseases include Graves' disease, Hashimoto's thyroiditis, autoimmune multiglandular syndrome, insulin-dependent diabetes mellitus, immune-mediated infertility, autoimmune Addison's disease, decidual pemphigus, herpes zoster, vitiligo, self Immune hemolytic anemia, autoimmune thrombocytopenic purpura, pernicious anemia, myasthenia gravis, multiple sclerosis, Giant-Barre syndrome, stiff man syndrome, acute rheumatic fever, sympathetic ophthalmitis, Goodpasture syndrome, Systemic lupus erythematosus, rheumatoid arthritis, systemic necrotizing vasculitis, Wegener's granulomatosis, antiphospholipid syndrome, Sjogren's syndrome, scleroderma, accelerated post-transplant arteriosclerosis, graft-versus-host disease, Crohn's disease, or tuberculosis It is. |