| abstract |
Of formula (I): [Chemical 1] In which X is of the formula> CR 1 R 2 or> SO 2 ; Y is of the formula> NH or> CR 1 R 2 ; Z is of the formula> C═O or> CH 2 or a direct bond; R 1 is hydrogen and R 2 is hydrogen, carboxy, or hydroxy; or R 1 and R 2 together represent an oxo group, a methylenedioxy group, or a hydroxyimino group; R 3 is hydrogen or lower alkyl; R 4 represents a 2 hydrogen atom or an oxo group or a hydroxyimino group; R 5 is hydrogen, lower alkyl, or halogen; R 6 is hydrogen, lower alkoxy, or carboxy; Compounds in which R 7 and R 8 are each hydrogen, lower alkyl, or halogen, and pharmaceutically acceptable salts and esters thereof may be acute or such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis Used to treat or prevent chronic neurodegenerative diseases or conditions, or secondary symptoms for acute ischemic events such as heart attack, stroke, or head injury, or to protect against ischemic damage to surrounding organ tissues Can be done. |