| abstract |
The present invention relates to analogs and derivatives of dinucleoside polyphosphates having the formula (I), or pharmaceutically acceptable salts thereof, one or more of the following: treatment of ischemia, induction of ischemic tolerance For use in the modification of cerebral ischemia, to delay the onset of the hypoxic depolarization phase when an ischemic event is triggered; as a neuroprotective agent; as a tissue protective agent; to treat pain; and to treat inflammation In which X is selected, where X 1 and X 2 are independently selected from H, Cl, Br and F; each Y is independent from S and O They are selected; each Z is -CX 3 X 4 -, - NH -, - selected O- than independently; wherein X 3 and X 4 is selected H, Cl, from Br and F; B 1 and B 2 is independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S 1 And S 2 ribose, open-chain ribose, 2'-deoxyribose, 3 'are independently selected from deoxyribose and arabinofuranoside. V is selected from 0, 1, 2, 3, 4 and 5; W is selected from 0, 1, 2, 3, 4 and 5; and V plus W is an integer from 2 to 6 It is. |