| abstract |
The present invention relates generally to the fields of protein, diagnosis, therapy, and nutrition. More particularly, the present invention provides a GM- having a profile of measurable physiochemical parameters that represents, is related to or forms the basis of one or more pharmacological attributes. Isolated protein molecules in or related to the short chain 4 helix bundle superfamily such as CSF, IL-3, IL-4 and IL-5, or GM-CSF-Fc, IL-3Fc, IL-4Fc And a chimeric molecule thereof comprising at least a portion of a protein molecule such as IL-5Fc. The present invention further contemplates the use of isolated proteins or chimeric molecules in a series of diagnostic, prophylactic, therapeutic, nutritional and / or research applications. |