| abstract |
The present application discloses a novel process for preparing himbacin analogs that are useful as thrombin receptor antagonists. This process is based in part on the use of base-promoted dynamic epimerization of chiral nitro centers. The chemistry taught herein can be illustrated by the following. The present application provides a novel process for preparing compound 11 from compound 1, which provides improved yield and elimination of the need for chiral intermediates. |