| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6859
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0038
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2006-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2008-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2008526889-A |
| titleOfInvention |
Targeted chimeric molecules for cancer therapy |
| abstract |
The present invention relates to a chimeric cancer therapy molecule comprising a target site and an anti-cell growth site. In a specific example, the anti-cell proliferation site can include a cytotoxic agent or an apoptosis inducing factor. In a particular example, the anti-cell proliferation mechanism of the chimeric molecule includes an apoptotic pathway. In further embodiments, the chimeric molecules of the invention provide sensitivity to chemotherapy in cells that are resistant to chemotherapy. In accordance with the present invention, one or more chemotherapeutic-resistant cancer cells are chemistryd in an individual comprising administering to the individual a therapeutically effective amount of a chimeric molecule comprising a cell-specific targeting site and an anti-cell proliferation site. Methods are provided for imparting or restoring sensitivity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10683362-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10920211-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017140051-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014515921-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017140029-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022033246-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11535838-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10738295-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012506394-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323239-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019531721-A |
| priorityDate |
2005-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |