abstract |
【Task】 The present invention relates to viral vectors that target cancer cells. [Solution] The viral vector of the present invention is an adenovirus having a PEG-3 promoter that drives the expression of viral genes E1A and E1B. The PEG-3 promoter exhibits increased activity in malignant cells. The adenovirus of the present invention exhibits increased replication in malignant cells, thereby causing a cytopathic effect. The viral vectors of the present invention can contain additional genes of interest and / or can alter capsid proteins. This can enhance cancer cell infection and / or target cancer cell infection. Additional cell types that arise from pathological conditions in which the PEG-3 promoter is selectively activated include those that produce allergies, autoimmune reactions, and inflammatory reactions, including the present invention It becomes a therapeutic target for viral vectors. [Selection] Figures 1A and 1B |