| abstract |
This invention relates to (1R) -1-[({(2R) -2-amino-3-[(8S) -8- (cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo [1,2- a] pyrazin-7 (8H) -yl] -3-oxopropyl} dithio) methyl] -2-[(8S) -8- (cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo [1,2 -A] pyrazin-7 (8H) -yl] -2-oxoethylamine is converted to morphine, analogs or morphine derivatives, sodium channel inhibitors, non-steroidal anti-inflammatory agents (AINS), glutamatergic inhibitors, tricyclic It relates to a product for the simultaneous, separate or sequential therapeutic use for the treatment or prevention of pain, comprising in combination with an analgesic selected from depressants and gaba agonists. |