| abstract |
The present invention relates to a partially reduced isoquinoline derivative compound having a sec-butyl group as a substituent at the 3-position and having a calpain inhibitor activity. The compounds according to the invention include (3-sec-butyl-1-oxo-2,3-dihydro-1H-isoquinolin-4-ylidene) -acetic acid and (3-sec-butyl-1-thioxo-2,3 Included are esters or amides derived from -dihydro-1H-isoquinolin-4-ylidene) -acetic acid. The compound represented by the general formula I or II can be used for preventive treatment or therapeutic treatment of degenerative diseases. |