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filingDate 2005-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2008-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2008523027-A
titleOfInvention Tetrahydropyridin-4-ylindoles with a combination of affinity for the dopamine-D2 receptor and a serotonin resorption site
abstract [Chemical 1] The present invention is a group of novel tetrahydropyridin-4-yl indoles having an affinity about serotonin reuptake inhibitory and dopamine -D 2 receptor is a dual activity system, manufacturing method, and the tetrahydropyridine of these compounds -4 -It relates to a novel intermediate useful for the synthesis of ylindoles. The invention also relates to the use of the compounds disclosed herein for the manufacture of medicaments that provide advantageous effects. The present invention relates to novel tetrahydropyridin-4-ylindoles of formula (I) and their tautomers, stereoisomers, prodrugs, N-oxides, pharmaceutically acceptable salts, hydrates and relates solvates, where -R 1 is hydrogen, halogen, alkyl (C 1-3) or alkoxy (C 1-3), CN or CF 3, -R 2 is hydrogen or alkyl (C 1-3 ), and, -R 3 is hydrogen or alkyl (C 1-3), -Z is hydrogen or alkyl (C 1-3), alkoxy (C 1-3) or alkylthio (C 1-3) , -A is hydrogen or alkyl (C 1-3 ), or -A and Z together are saturated or (partially) optionally substituted by halogen, alkyl (C 1-3 ) or phenyl Unsaturated A 5- or 6-membered ring, wherein ring Z represents carbon, sulfur or nitrogen.
priorityDate 2004-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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