http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008522994-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D267-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D267-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-553 |
| filingDate | 2005-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008522994-A |
| titleOfInvention | Malonamide derivatives as inhibitors of γ-secretase for the treatment of Alzheimer's disease |
| abstract | The present invention provides a compound of the general formula (I) for the treatment of Alzheimer's disease wherein R is halogen, lower alkyl, or lower alkyl substituted by halogen; R 1 is hydrogen, lower alkyl, or Lower alkyl substituted by halogen or hydroxy, or lower alkenyl, — (CH 2 ) n -cycloalkyl, — (CH 2 ) n —COR ′ (wherein R ′ is lower alkoxy, hydroxy, Or benzyl optionally substituted with halogen, or — (CH 2 ) n -morpholinyl; R 2 is hydrogen, lower alkyl, di-lower alkyl, or halogen Or lower alkyl substituted by hydroxy, or benzyl or cycloalkyl; 3, or it is benzyl optionally substituted lower alkyl, or whether it is lower alkyl substituted by halogen, or by two halogen atoms, or - (CH 2) n - cycloalkyl or - (CH 2) n is pyridinyl; X is —CR 4 R 4 ′ — or —CR 4 R 4 ′ —O—; R 4 / R 4 ′ are, independently of one another, hydrogen, halogen, lower alkyl, lower Alkoxy, hydroxy, or —CH 2 -2- [1,3] dioxalane-; n is 0, 1 or 2], pharmaceutically suitable acid addition salts thereof, and optical thereof All forms of enantiomerically pure enantiomers, racemates or diastereomers, and mixtures of diastereomers. |
| priorityDate | 2004-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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