| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04 |
| filingDate |
2005-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2008521920-A |
| titleOfInvention |
Antibody drug conjugates and methods |
| abstract |
The present invention relates to a compound of formula (I) wherein one or more 1,8 bis-naphthalimide drug moieties (D) of formula (IIa) and (IIb) are covalently attached to antibody (Ab) by a linker (L). ) -Antibody-drug conjugate (ADC) compounds. The present invention also relates to pharmaceutical compositions comprising an effective amount of an ADC of formula I for the treatment of hyperproliferative disorders and other diseases. The invention also relates to a method of killing or inhibiting the growth of tumor cells or cancer cells comprising administering to a patient an effective amount of an ADC of formula (I). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008536999-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107982545-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10967071-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015516012-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107982545-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009517467-A |
| priorityDate |
2004-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |