http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008521879-A

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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-003
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08
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filingDate 2005-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2008521879-A
titleOfInvention GEM-difluorinated C-glycopeptides and their preparation and storage of biological materials and / or use in cryosurgery
abstract The present invention relates to gem-difluorinated C-glycopeptide compounds having the chemical formula (I), wherein N is an integer between 1 and 5, and R 4 = H, AA 1 , AA 1 -AA 2 , R 5 = OH, AA 1 , AA 1 -AA 2 , AA 1 and AA 2 are independent and are amino acids having non-functional side chains, R 1 , R 2 , R 3 Are independent groups, one of which is equal to formula (II), where n is an integer between 3 and 4, Y, Y ′ are independent groups, where Y Y ′ = H, OR, N 3 , NR′R ″, SR ′ ″, where R = H, benzyl group, trimethylsilyl group, tert-butyldimethylsilyl group, tert-butyldiphenylsilyl group, Acetate group, R ′, R ″ = H group, alkyl group, allyl group, benzyl group, tosylate group, C (= 0) -alkyl group, C (= O) -Bn group, R ″ '= H group, alkyl group, acetate group, R 6 is particularly H group, CH 3 group, CH 2 OH group, CH 2 -glycoside group, CH 2 -OGP group, where GP is a protecting group such as alkyl group, benzyl group, trimethylsilyl group, tert-butyldimethylsilyl group, tertbutyldiphenylsilyl group, acetate group R 7 = OH, OGP ′, NH 2 , N 3 , NHGP ′, NGP′GP ″, where GP ′ and GP ″ are alkyl groups, benzyl groups, trimethylsilyl groups, tert-butyldimethyl Whether R 8 is a protecting group such as a silyl group, tert-butyldiphenylsilyl group, acetate group or the like, and R 8 is a hydrogen atom H or a free or protected alcohol functional group. This applies in particular to biological material storage and cryosurgery.
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