| abstract |
The present invention relates to 2-methylene-18,19-dinor-vitamin D analogs, specifically 2-methylene-18,19-dinor-1α-hydroxy-homopregnacalciferol, and pharmaceutical uses thereof. Disclose. Since this compound shows remarkable activity when it inhibits the proliferation of undifferentiated cells and induces differentiation into monocytes, it is used as an anticancer agent, as well as skin diseases such as psoriasis and wrinkles, sagging skin, dry skin. And uses for the treatment of skin conditions such as insufficient sebum secretion. The compounds can also be used for the treatment of human autoimmune disorders or inflammatory diseases as well as renal osteodystrophy because of low, if any, calciumemia activity. The compounds can also be used for the treatment or prevention of obesity. [Selection] Figure 1 |