| abstract |
Disclosed are compounds of formula (A) and pharmaceutically acceptable salts useful for the treatment of metabolic disorders associated with insulin resistance, leptin resistance or hyperglycemia. The compounds of the present invention include inhibitors of protein tyrosine phosphatases, particularly protein tyrosine phosphatase 1B (PTP-1B), which are useful in the treatment of diabetes and other PTP-mediated diseases such as cancer, neurodegenerative diseases and the like. . Also disclosed are pharmaceutical compositions comprising the compounds of the present invention and methods of treating the above conditions using such compounds. |