| abstract |
A pharmaceutical composition for topical application is disclosed, the composition comprising a nucleic acid as therapeutic agent, an excipient comprising liposomes and a pharmaceutically acceptable carrier for them. The excipient is formulated so that it contains amphoteric liposomes having an isoelectric point of 4 to 7.4 and the composition has a pH in the range of 3 to 5. The composition is administered in the form of a colloidal suspension, which is a substantially neutral suspension consisting of nucleic acids and excipients that may be more suitable for long-term storage of the composition with appropriate acidifying means at the time of use. Can be buffered to a lower pH. Alternatively, the composition can be lyophilized at a lower pH for subsequent reconstitution immediately prior to use with a suitable aqueous medium, such as, for example, substantially unbuffered water or saline. |