| abstract |
The present invention relates to novel diuretic compounds containing at least one heterocyclic nitric oxide donor group, or pharmaceutically acceptable salts thereof, and at least one heterocyclic nitric oxide donor group containing at least one heterocyclic nitric oxide donor group. A novel composition comprising a diuretic compound and optionally at least one nitric oxide enhancing compound and / or at least one therapeutic agent is described. The present invention also includes at least one diuretic compound of the invention comprising at least one heterocyclic nitric oxide donor group, and optionally at least one nitric oxide enhancing compound and / or at least one therapeutic agent. Novel compositions and kits comprising are provided. The present invention also treats (a) conditions resulting from overhydration and / or electrolyte retention; (b) treats cardiovascular disease; (c) treats renovascular disease; (d) treats diabetes (E) treat diseases resulting from oxidative stress; (f) treat endothelial dysfunction; (g) treat diseases caused by endothelial dysfunction; (h) treat cirrhosis; (j) eclampsia (K) treat osteoporosis; (l) treat nephropathy; (m) treat peripheral vascular disease; (n) treat portal hypertension; (o) central nervous system And (p) methods of treating sexual dysfunction are provided. The heterocyclic nitric oxide donor is preferably furoxan, sydnonimine, oxatriazol-5-one and / or oxatriazole-5-imine. |