| abstract |
The present invention provides compounds of formula (I) and formula (II) useful for modulating the biological activity of protein tyrosine phosphatase-1b (PTP1B) enzyme. The compounds of the present invention can be used to treat diseases and / or conditions in which the PTP1B enzyme is a factor. Such diseases and / or conditions include type 1 diabetes, type 2 diabetes, insufficient glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis Including, but not limited to, arteriosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipocyte tumor, adipocyte cancer, liposarcoma, dyslipidemia, cancer, and neurodegenerative disease It is not a thing. |