| abstract |
The present invention relates to antibodies, antibody fragments or derivatives thereof that are particularly advantageous for specifically binding / interacting with at least one epitope of the extracellular or intracellular domain of a mammalian EAG1 ion channel, and nucleic acid molecules encoding them, And a vector containing the nucleic acid molecule. The invention further relates to methods for the preparation of the antibodies, antibody fragments or derivatives thereof, and pharmaceutical compositions containing them. Further disclosed herein is the use of the antibody, antibody fragment or derivative thereof and a diagnostic composition containing the component. The present invention also relates to a method for evaluating the presence of EAG1-expressing cells and a method for blocking EAG1 function in the cells. The present invention further relates to a method for treating a disease utilizing the antibody or antibody fragment or derivative thereof. |