| abstract |
The present invention relates to substituted benzoylguanidines of the formula (I), in which R1 to R8, X and Y have the meaning given in the claims and their pharmaceutically acceptable salts, These are substituted acylguanidines that inhibit the cellular sodium / proton antiporter (Na + / H + exchanger, NHE). Compounds of formula (I) and pharmaceutically acceptable salts thereof are secondary to NHE activation or disease caused by activated NHE as a result of NHE inhibition, and secondary damage caused by NHE. Suitable for prevention and treatment of diseases. [Chemical 1] |