http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008519060-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-24 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2005-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008519060-A |
| titleOfInvention | Compositions and methods for preparing 13-deoxyanthracyclines |
| abstract | Provided are compositions and methods for preparing 13-deoxyanthracyclines. The present invention relates to 13-benzenesulfonylhydrazone anthracyclines useful for improving the synthesis yield of 13-deoxyanthracyclines, and the reduction reaction is kept at about 55-64 ° C. without stirring or shaking. Of 13-benzenesulfonylhydrazone anthracyclines to 13-deoxyanthracyclines. The reaction is complete with the addition of aqueous bicarbonate to form 13-deoxyanthracycline and a precipitate. The precipitate is filtered and the precipitate and filtrate are extracted separately with an organic solvent. Crude 13-deoxyanthracycline can be converted to 5-imino-13-deoxyanthracycline by reacting with a methanol solution of ammonia water. The reaction can be easily purified by using an acidic pyridinium salt that does not require neutralization of the reaction solution or extraction of the product instead of a strong acid. [Selection figure] None |
| priorityDate | 2004-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.