| abstract |
Starting from Streptomyces sp fermentation broth, tacrolimus (I) (17-allyl-1,14-dihydroxy-12- [2- (4-hydroxy-3-methoxycyclohexyl) -1-methylvinyl] -23,25- Dimethoxy-13,19,21,27-tetramethyl-11,28-dioxy-4-azatricyclo- [22.31.0 4.9 ] octacos-18-en-2,3,10,16-tetraone) Purification and recovery methods. This process is particularly advantageous in terms of impurity separation productivity and selectivity. |