| abstract |
[Chemical 1] The present invention relates to novel pyrimidine imidazoles and aza-indoles according to formulas (I) and (II), pharmaceutical compositions containing them and those in the treatment of disorders mediated by one or more estrogen receptors. Is intended for use. The compounds of the present invention, alone or in combination with a progestogen or progestogen antagonist, are disorders associated with estrogen depletion, such as hot flashes, vaginal dryness, osteopenia and osteoporosis; breast, endometrium, neck and It is useful in the treatment of prostate hormone-sensitive cancers and hyperplasias; endometriosis, uterine fibroids, osteoarthritis, and as a contraceptive. |