| abstract |
The present invention relates to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of diseases and disorders mediated by agonists and antagonists of progesterone receptors. Clinical uses of these compounds include contraception; secondary amenorrhea, dysfunctional bleeding, uterine leiomyomatosis, endometriosis; polycystic ovary syndrome, endometrium, ovary, breast, colon, prostate cancer and Associated with the treatment and / or prevention of adenocarcinoma; or minimizing the side effects of periodic menstrual bleeding. Another application of the present invention includes stimulation of food intake. |