| abstract |
The present invention inhibits protein tyrosine kinases, particularly c-fms kinase, formula (I): [Chemical 1] [Wherein A, X, R 2 and W are indicated in the specification] And solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof. Methods for treating autoimmune diseases and diseases with an inflammatory component with compounds of formula (I), treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small cell lung cancer Methods and pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory and neuropathic, as well as osteoporosis, Paget's disease and bone resorption mediates pathological conditions Also provided are methods of treating other diseases including arthritis, prosthetic organ failure, osteolytic sarcoma, myeloma and metastasis of tumor to bone. |