| abstract |
The present invention provides compositions and methods for treating or preventing bacterial infections. Also provided by the invention is a recombinant cell that expresses a Lewis b carbohydrate epitope. In one aspect, the present invention provides a fusion polypeptide comprising a first polypeptide operably linked to a second polypeptide, the first polypeptide comprising: a) an O-linked glycan Above, glycosylated by α1,3 / 4 fucosyltransferase, α1,2 fucosyltransferase, β1,3 galactosyltransferase and β1,3, N-acetylglucosaminyltransferase, or b) on N-linked glycans And glycosylated by α1,3 / 4 fucosyltransferase, α1,2 fucosyltransferase and β1,3 galactosyltransferase; and the second polypeptide comprises at least one region of an immunoglobulin polypeptide. |