| abstract |
Described are efficient synthetic pathways for the imidazooxazoles and imidazothiazoles of formula (I), which are inhibitors of the p38 MAP kinase pathway, useful as therapeutics for disease conditions such as inflammation and autoimmune responses. In one embodiment, the present invention provides a high yield method for preparing imidazooxazole and imidazothiazole compounds, such as, for example, compounds of formula I and formula Z, which can be used, for example, as anticancer agents and p38 MAP kinase inhibitors. In another embodiment, any method of the present invention for preparing a compound, such as, for example, a method of preparing a compound of formula I or formula Z, comprises pharmaceutically acceptable salts, prodrugs, metabolites of the compound, It can be used to prepare analogs or derivatives. |