| abstract |
The present invention is directed to formula (I) wherein R 1 is hydrogen, halogen, lower alkyl, lower alkynyl, cycloalkyl, heterocycloalkyl, benzyl, cyano, lower alkoxy, OCF 3 , —NHR, —NHC (O ) R or —NHSO 2 R; R 2 is lower alkyl substituted by halogen; R 3 is hydrogen, methyl or aryl; R is lower alkyl, cycloalkyl or aryl) It relates to the indicated substituted imidazo [1,5-a] [1,2,4] triazolo [1,5-d] [1,4] benzodiazepine derivatives, and pharmaceutically acceptable acid addition salts thereof. This type of compound exhibits high affinity and selectivity for the GABA A α5 receptor binding site and may be useful as a nootropic drug or in the treatment of cognitive impairment, anxiety, schizophrenia or Alzheimer's disease. It was found. |