| abstract |
The present invention provides compounds of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as disclosed herein. The invention also provides syntheses for preparing such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, particularly CDK2, for inhibiting neovascularization and for treating cancer, particularly breast cancer, colon cancer, prostate cancer, and lung cancer. |