http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008512107-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 2005-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008512107-A |
| titleOfInvention | Methods for promoting somatic mutations and their use in proteomics |
| abstract | The present invention relates to a method for promoting the induction of somatic mutations in vitro. In the method of the invention, expression of at least one cDNA expressing a modified version of the AID gene in a cell to be mutated under culture conditions and in a suitable medium Is included. In the modified version produced by the AID gene above, all three hydrophobic amino acids leu189, phe193, and leu196 have been replaced by alanine mutations. The present invention can be used to induce mutations in Burkitt lymphoma BL2. The present invention also induces mutations in immunoglobulin genes of immortalized antibody producing cells (eg, mouse hybridoma cells, human hybridoma cells, or human B cell lines immortalized with Epstein-Barr virus (EBV)). Can also be used for. |
| priorityDate | 2004-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.